An Improved Synthesis of Benzocycloalkanone Derivatives
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概要
- 論文の詳細を見る
A convenient and improved annulation method for the synthesis of bicyclic ketones was developed. A 2,2-dimethyl-6-(2-phenylsulfonyl)ethylcyclohexanone was converted into a sulfonylester by the addition of ethyl acetate and subsequent dehydration. A Dieckmann type condensation of the sulfonylester followed by desulfonylation afforded the 8,8-dimethyl-l,2,3,4,5,6,7,8-octahydronaphthalene-2-one in good yield. This annulation method was also applicable for the synthesis of the benzocyclooctanone derivative.
- 公益社団法人日本薬学会の論文
- 2004-01-01
著者
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Wada Akimori
Kobe Pharmaceutical University
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ITO Masayoshi
Kobe Pharmaceutical University
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Ono Naomi
Faculty Of Pharmaceutical Sciences Kumamoto University
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Ono N
Kobe Pharmaceutical University
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Sawada Kozo
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Sawada K
Kobe Pharmaceutical University
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SAWADA Kyoko
Kobe Pharmaceutical University
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ONO Naomi
Kobe Pharmaceutical University
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Ito Masayoshi
Kobe College Pharm.
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Wada Akimori
Kobe Pharm. Univ.
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