Effects of dietary zinc and cadmium on tissue selenium concentration and glutathione peroxidase activity in rats fed DL-selenomethionine or sodium selenite.

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概要

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• The effects of dietary zinc (Zn) and cadmium (Cd) on tissue selenium (Se) concentration and glutathione peroxidase (GSH-Px) activity were studied in weanling male Wistar rats. One group of rats was fed a purified diet based on casein and sucrose, and the other rats used in a 2×2×2 factorial arrangement of treatment were fed this diet supplemented with 0.1mg Se/kg, either as DL-selenomethionine or sodium selenite and plus 100mg Zn/kg as zinc sulfate or 5mg Cd/kg as cadmium chloride or both for 4 weeks. Se concentrations in plasma, erythrocytes, muscle, heart, and liver were significantly elevated by Zn. Cd significantly decreased Se concentration in muscle. Addition of Zn to the diets markedly increased (p<0.001) hepatic GSH-Px activity. However, Cd in the diets produced a significant increase (p<0.001) in erythrocyte GSH-Px activity. These results indicate that Zn level of marginal deficiency(8.6mg/kg diet) can decrease Se availability and a small excess of Zn increases Se availability for hepatic GSH-Px activity.

• 財団法人 学会誌刊行センターの論文

著者

• Yin Shi-an

  Institute Of Nutrition And Food Hygiene Chinese Academy Of Preventive Medicine

• Hosokawa Yu

  Division Of Maternal And Child Nutrition The National Institute Of Nutrition

• Sato Ikuo

  Division Of Bioresource Science Graduate School Of Horticulture Chiba University

• NIIZEKI Shiro

  Divisiton of Maternal and Child Nutrition, The National Institute of Health and Nutrition

• TOJO Hitomi

  Divisiton of Maternal and Child Nutrition, The National Institute of Health and Nutrition

• YAMAGUCHI Kenji

  Tokyo Kasei University

• HOSOKAWA Yu

  Division of Maternal & Child Nutrition, The National Institute of Health and Nutrition

• HOSOKAWA Yu

  Divisiton of Maternal and Child Nutrition, The National Institute of Health and Nutrition

• SATO Ikuo

  Divisiton of Maternal and Child Nutrition, The National Institute of Health and Nutrition

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