The Necessity of Dietary Vitamin B6 to Selenium Biopotency for Tissue Selenium and Glutathione Peroxidase in Rats.

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Necessity of dietary vitamin B6 to the biopotency of sele-nium (Se) for the levels of Se and glutathione peroxidase (GSH-Px) in tissues was investigated. Male Wistar 12-week-old rats were fed a vitamin B6-Se-deficient basal diet for 3 week, and then the rats were divided into 6 groups. One group was fed the basal diet, the others were fed the diet supplemented with 250 1cg vitamin B6/100g as pyridoxine⋅ HCl, or 0.25mg Se/kg as Na2SeO3 (SeL) or DL-selenomethionine (Se-Met), or both (SeL+B6 or Se-Met+B6) for 10 week. The levels of Se and GSH-Px in erythrocytes and muscle were significantly higher in vitamin B6-supple-mented groups than in vitamin B6-deficient groups. There was little effect of this vitamin deficiency on Se level in liver of rats fed SeL; however, a higher Se level in liver was observed in vitamin B6-deficient rats fed Se-Met than in the corresponding B6-supplemented rats. A significant decrease of GSH-Px activity in liver was found in vitamin B6-deficient animals fed Se-Met compared with vitamin B6-supplemented animals, whereas no significant decrease was observed in those fed SeL. These results suggest that this vitamin is involved in the transport and deliver-ance of Se in plasma to the other tissues and the incorporation of Se from Se-Met to GSH-Px in liver.
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