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In the early 1970s, when human fibrinogen preparation of high concentration became available, fibrin sealing technique was employed for wound management after surgery, This report is about the bacteriological characteristics of the fibrin adehsion system. Twelve kinds of bacteria were inoculated on fibrin slants. Some bacteria grew on the slants after five days. The fibrin slants were completely dissolved by S. aureus and S. marcescence, and incompletely by P. cepacia, P. aeruginosa and S. epidermidis. To clarify the relationship between bacterial number and fibrinolysis, the series of 10-fold dilutions of S. aureus were inoculated on the fibrin slants. Growth of S. aureus was remarkable. The fibrin saint on which 10 cells/ml were inoculated was dissolved after only two days. Even in the case of 10 cells/ml inoculum fibrinolysis was observed after twelve days. Dental plaque from six patients was cultivated on fibrin slants. Identification of these microorganisms based on certain biochemical test reactions showed that the plaque contained microorganisms which dissolved the fibrin sealants. It should be kept in mind that fibrin sealants can be dissolved by some oral microorganisms when fibrin sealing technique is used.
社団法人日本口腔外科学会の論文