Clinical administration of gabexate mesilate (FOY) to DIC occured in patients with oral cancer.

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Two cases of DIC accompanied by oral cancer arc presented. Case 1: 35-year-old-male was diagnosed of pre-DIC because the examination data of coagulation and fibrinolysis were abnormal. By gabexate mesilate (1, 800mg/day) administration, they changed for the better. Case 2: 66-year-old-male was diagnosed of acute DIC because of hemorrhagic tendency and MOF (multiple organ failure). He fell in renal, hepatic, respiratory failure and mechanical ventilation was immediately given. By the administration of gabexate mesilate (1, 600 mg/day), methylpredonisolone and prostaglandin E1, the findings of the coagulation and fibrinolysis were improved, subsequently his organic functions gradually became better. Gabexate mesilate, which was developed for the therapy of pancreatitis, has shown efficiency in the treatment of DIC. We gave it to the patients of DIC complicated by oral cancer, and we found it useful for DIC after the maxillofacial surgery.
社団法人日本口腔外科学会の論文