Experimental radiosensitizer therapy for malignant tumor transplanted to nude and conventional mice. 2. Radiosensitive effect of dinitroimidazole ethanol for Ehrlich solid carcinoma.:(2) Radiosensitive effect of Dinitroimidazole ethanol for Ehrlich solid

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Dinitroimidazole ethanol is a new radiosensitizer of hypoxic tumor cells. The purpose of our study is to compare the sensitizer enhancement of misonidazole and dinitroimidazole ethanol. Methods and evaluation: Battelle Columbus Laboratories Protocol. Radiation: 60Co 15 Gy local radiation. These radiosensitizers were administered into the mice's abdomen before 30 minutes of local irradiation 60Co 15 Gy. Tumor: Ehrlich solid carcinoma. On the first day of the experiment, 2-3 pieces of 1-3mm tumor blocks in Eagle's MEM medium were transplanted to subcutaneous region of the right thigh of each mouse. Subjects: Male conventional DDY mice, conventional ICR mice and nude ICR mice.(10 weeks, about 20g) Results: The most effective case was DNIE 10 mg+60Co 15 Gy in DDY mice and second case was DNIE 10mg+60Co 15 Gy in conventional ICR mice. There was no significant differences in tumor growth among the control group, 60Co 15 Gy group and DNIE 2mg+60Co 15 Gy group with regard to Ehrlich solid carcinoma.
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