Experimental radiosensitizer therapy for malignant tumor transplanted to nude mice. 4 Radiosensitive effect of imidazole compounds for human mouth floor-tongue poor differentiated epidermoid carcinoma.:(4) Radiosensitive effect of imidazole compounds for

概要

論文の詳細を見る
We had demonstrated in the former investigation that the effectiveness of imidazole radiosensitizer that is misonidazole, dinitroimidazole ethanol and 5-methoxy carbonyl-2-methyl sulfinyl-1-methyl imidazole for Ehrlich solid carcinoma transplanted into nude and conventional mice. In this study, we report the effectiveness of imidazole radiosensitizer for oral malignant tumor. Methods and evaluation: Battelle Columbus Laboratories Protocol. Tumor: KB cell=human mouth floor-tongue poorly differentiated epidermoid carcinoma. Tumors were transplanted to subcutaneous of the right thigh of each mouse. Subjects: Male nude CD-1 (ICR) mice (10 weeks age, 20-25 body weight). Radiosensitizer: misonidazole (MISO), dinitroimidazole ethanol (DNIE) and 5-methoxy carbonyl-2-methyl sulfinyl-1-methyl imidazole (KIH-3). Radiation: 60Co 15 Gy local radiation. These radiosensitizers were administrated into the abdomen of the mice prior to 30 minutes of local irradiation. Results: On KB cell of nude ICR mice, tumor reduction effect was evaluated on MISO 20 mg+60Co 15 Gy group, but tumor recurred after 4 days, therefore the sensitization effect was not evaluated. Radiosensitization effect was evaluated DNIE 10 mg +60Co 15 Gy group. There is no effect in KIH-3 40 mg +60Co 15 Gy group.
社団法人日本口腔外科学会の論文