悪性黒色腫に対する炭酸ガスレーザーの応用

概要

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It was recognized that operation was the most successful therapeutic method for treatment of malignant melanoma. However, the primary malignant melanoma of the oral mucosa did not allow a wide surgical excision and prognosis was unfavorable in most cases. This paper described a case of operation using carbon dioxide laser instead of surgery. A 57-year-old man visited our clinic with a complaint of pigmentation on palate mucosa. Intraoral examination revealed a mottled black-brown area on the hard and soft palate. Their surfaces were smooth except the lesion with a small swelling on the center of the tumo r. Clinical diagnosis was a suspected malignant melanoma. Chemotherapy with VCR, ACNU and D TIC was performed, resulting in no regression. Then, we performed a radical neck dissection for left submandibular lymphnode, an upper neck dissection for right submandibular lymphnode and laser surgery with CO2 laser for platate. The lesion was vaporized at an output of 10-30 W with the defocused and continuous wave. After the surgical procedure, patient received adjuvant chemotherapy with VCR, ACNU and DTIC, and immunotherapy with TFT-310. At follow up 3 years postoperatively, the patient was free of symptoms.
社団法人日本口腔外科学会の論文