A metachronous double cancer of tongue and esophagus: Report of a case.

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Clinicopathological findings of a metachronous double cancer in the tongue and the esophagus are reported in this paper. A 42-year-old male with endophytic and welldifferentiated squamous cell carcinoma, which occurred in the right body of the tongue, was referred to the Dental Hospital of Iwate Medical University. The carcinoma disappeared clinicopathologically at 3 rd month after infusions of Bleomycin (60mg) and 5-FU (4, 800mg) with irradiations of 60Co (54 Gy) and radium needling (30 Gy). After 2 years, however, marked dysplasia of the epithelium in the left tongue margin appeared. It developed into an invasive carcinoma 2 years later, and then a partial resection of the tongue was performed. Poorly differentiated squamous cell carcinoma of the esophagus appeared after 8 years. Irradiation of 60Co (40 Gy) after surgery for the carcinoma was carried out. Aftenvords, his post-therapeutic course was uneventful.