妊娠時に合併した舌癌の1例

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The occurence of malignant tumors during pregnancy is relatively rare, especially in regions distant from the genital organs, such as the tongue.<BR>A 25-year-old woman came to us complaining of a non-healing ulcer on the tongue. She was 37 weeks pregnant at the first examination. Biopsy showed squamous cell carcinoma.<BR>After drug-induced delivery of a healthy female child at 39 weeks, chemotherapy (arterial infusion of Peplomycin, total 88.7mg) and irradiation (Linac, total 60 Gy) were performed for about 50 days and then immunotherapies were started. These therapies were very effective and there were no recurrences after 31 months. She is pregnant again and her first child is growing normally.<BR>Malignant tumors during pregnancy entail many problems: the relationship between carcinogenesis and pregnancy, maternal and fetal immunological and hormonal problems, therapeutic problems such as drug-induced malformation, and others.<BR>This paper discusses the above topics and reviews the relevant literature.