移植腸骨へのヒドロキシアパタイト人工歯根の適用に関する実験的研究

概要

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The purpose of this study was to evaluate the application of hydroxylapatite implants (HA) with autogenous bone grafts for mandibular reconstruction. After autogenous iliac bone grafts were transplanted into rabbit mandibles, a HA was installed in the graft immediately (IM group), or 90 days (90 D group) or 180 days (180 D group) later. The animals were sacrificed 7, 14, 30, 60, 90 and 180 days after the HA installation. The healing processes were examined by a method, newly developed by us, of combining a hematoxylin-eosin staining with contact microradiography and fluorescense labeling of the same specimen, and the rate of HA-bone bonding was examined by bone morphometry.<BR>In the IM group, the HA-bone bonding tended to be deterred by conective tissues, and the rate of HA-bone bonding was less than that of the control group (HA installed in the mandible). However, in the 90 D and 180 D groups the bonding capacity was approximately the same as in the control group. In the 180 D group, a trabecular bone around the implant was less than in the 90 D group. Therefore, the 90 D group had better conditions for effective HA-bone bonding.<BR>From these results, it is concluded that in the clinical application of hydroxylapatite dental implants with autogenous bone grafts, the implantation should be performed not immediately after the bone graft, but before the trabecular bone resorption by advanced bone remodeling.