加齢がヒドロキシアパタイトと骨との結合に及ぼす影響について-ラット脛骨内に埋入後の組織所見-

概要

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The purpose of this study was to investigate the effect of aging on the healing process afterinstallation of hydroxylapatite (HA) implant into bone tissue. Three groups of eight male Wistar rats, aging 6 weeks (Young group), 12 weeks (Adult group), and approximately two years (Old group) were used in this experiment. Two implants were installed into the rats tibiae bilaterally. The animals were sacrificed 7, 14, 28, and 56 days after the installation, and 15μm hematoxvlin-eosin stained undecalcified sections were prepared. The healing processes were examined histologically.<BR>In the Young group, new trabecular bone was formed actively around the HA implant, and good HA-bone bonding was achieved rapidly compared to the Adult group. In the Old group, both the quantity of newly formed trabecular bone around the implant and the extent of HA-bone bonding were less than in the other groups. These results suggested that the activity of new bone formation after implantation declines with increasing age. Therefore, it is concluded that aging has disadvantages in the achievement of good HA-bone bonding.
社団法人日本口腔外科学会の論文