Genetic study on cleft lip and/or cleft palate. 2. Immunogenetic study by making use of HLA.:2. Immunogenetic study by making use of HLA

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152 patients with cleft lip and/or cleft palate (CL/CP) who visited the clinic of Second Department of Oral and Maxillo-facial Surgery, Tokyo Medical and Dental University Hospital were typed for HLA A, B, & C. The results of this population studies were as follows.(1) There were no antigens which showed the statistically significant association neither in male nor female patients with cleft lip alone (CL).(2) Aw 33 was significantly low only in the male patients with cleft lip and palate (CLP).(3) Aw 24 and Bw 52 were significantly high only in the male patients with cleft palate alone (CP). These results suggested that the HLAlinked susceptibility or resistant genes for CP or CLP respectively exist and that these types of clefts were different in forms of the involvement of HLA-linked genetic factors. The difference in the association of cleft with HLA between male and female might be explained by the multifactorial character of disease.
社団法人日本口腔外科学会の論文