Studies on changes of hardened .ALPHA.-TCP in vivo.

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α-tricalcium phosphate (α-TCP) granules were mixed with calcium phosphate dibasic (DCPD) and hydrated to obtain hardened materials. These materials were shaped in the form of column (2×10 mm), and then implanted on the inferior surface of rabbit mandibles and in the muscle tissue with and without calvarial periosteum and soaked in simulated body fluid for 1, 3, and 6 months. The changes of the materials were evaluated microscopically and microradiographically. The surface resorption was recognized in all materials except ones soaked in simulated body fluid. The resorption was most prominent on the surface of the materials implanted on the mandibular bone. Microradiographic study showed the formation of white zone in the outer part of the materials implanted on the mandibular bone and in the muscle tissue with calvarial periosteum. The white zone was formed on the entire surface of the materials implanted on bone, however, it was only on partial surfaces of the materials where calcified tissue was formed when implanted in the muscle tissue with periosteum. The white zone formation was not recognized on the materials soaked in the simulated body fluid. It is concluded that the materials are resorbable in vivo, and the surface of the materials may develop the change, resulting in the decrease of radiolucency, in the circumstances where bone or calcified tissue is formed.
社団法人日本口腔外科学会の論文