Studies on hardened .ALPHA.-TCP implanted in rabbits for a long term.

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A long-term in vivo study on α-tricalcium phosphate (α-TCP) mixed with 11 weight % of calcium phosphate dibasic and hardened by hydration was performed. Hardened materials prepared in the form of columns (2×10 mm) were implanted on the inferior surface of the mandible and in the back muscle of rabbits. The materials were harvested with surrounding tissues after 1 or 1. 5 years' implantation and embeded in polyester resin (Regolac®). Serial thin sections were cut and hand-ground for microscopic and microradiographic evaluation. The material was shown to be well tolerated by bone and muscle tissue after long-term implantation. Direct bone contact to the material was seen when implated on the mandibular bone, and a very thin fibrous capsule was formed when implanted in the back muscle. All specimens showed resorption, though the resorption rate decreased in comparison with that reported in previous short-term experiments. The materials from the mandibular bone were no longer resorbed once the surface was covered with bone tissue and the materials from the back muscle showed diffuse signs of resorption throughout almost the entire surface. These findings suggested that dissolution of the material into body fluid is involved in resorption. The degree of the material resorption differed greatly depending on the material, even when implanted in the same tissue of the same rabbit, which may indicate that various kinds of calcium phosphate salts were formed and distributed irregularly in the material. In microradiographic study, a thin white zone was noted in the outer layer of the material implanted on the mandibular bone. It was not apparent or disappeared in severely resorbed areas. The formation of this zone may be related to bone formation or bone attachment to the material.
社団法人日本口腔外科学会の論文

Studies on hardened .ALPHA.-TCP implanted in rabbits for a long term.

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