口腔多発癌4例の臨床経過に関する検討

概要

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During the 16-year period from 1975 to 1990, 141 patients with oral squamous cell carcinomas were referred to our clinic. Seven of these patients (5%) had multiple primary oral cancer within the same tissues or organs according to the criteria of Moertel. Here we report on the four most recent of these seven patients. The four patients all had advanced stage (Stage III, IV), well-differentiated squamous cell carcinomas. Initial treatment of these four patients was chemotherapy and radiotherapy with surgery. Second primary tumors occurred in the buccal mucosa in 2 patients and in the gingiva and the tongue in the other two patients. All second primary tumors were early stage (Stage I, II), well-differentiated types. The average interval between the diagnosis of the initial primary and second primaly tumors was 5 years and 9 months. Two patients with third primary tumors had white lesions or erosion-like lesions in the oral mucosa during the observation period, or at the first examination. The average interval between the diagnosis of the second and third primary tumors was one year. The results of the present study suggest that careful surgical excision of various mucosal lesions found after the treatment of oral cancer is very important, especially because precancerous lesions of patients with oral cancer have malignant potential.
社団法人日本口腔外科学会の論文