歯磨剤添加3薬物の歯周疾患予防効果に関する研究

概要

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Three different agents were added to dentifrice used daily for the prevention and treatment of periodontal diseases and the effects of the three dentifrices were evaluated.<BR>Healthy adult women were selected as subjects. Twenty were assigned to a group using a dentifrice containing Tranexamic acid, 19 to a group using a dentifrice containing stearylglycyrrhetinate, and the remaining 20 to a group using a dentifrice containing α-amylase. They were instructed to apply each dentifrice with a toothbrush for one month continually. All subjects received 5 examinations of the periodontal tissue at intervals of 7 days and changes of subjective and objective conditions were observed at each time.<BR>The following results were obtained: the dentifrice containing Tranexamic acid was effective in the reduction of gingival inflammation, in the regression of gingival bleeding and swelling and tooth mobility; the dentifrice containing Stearylglycyrrhetinate was effective in the removal of bad breath and oral ill feeling; the dentifrice containing α-amylase, however, was not significantly effective, compared to the other two dentifrices.<BR>Therefore, Tranexamic acid was encouraging when added to the dentifrice as an agent for preventing gingival diseases, and so with Stearylglycyrrhetinate for removing bad breath.
有限責任中間法人日本口腔衛生学会の論文