Penicillium concavo-rugulosum Abeによって生産されるインドール・アルカロイド類の吟味

概要

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In connection with the biogenesis of the interconvertible indole alkaloids, rugulovasine A and B, the authors have examined the whole alkaloids produced in the surface cultures of Penicillium concavo-rugulosum Abe for the existence of such alkaloids as agroclavine and elymoclavine by means of thin layer chromatography. As a result, it has been found that in the said cultures there exist several indole alkaloids each of which agree well with isochanoclavine-(I), chanoclavine-(II), dihydrorugulovasine A or dihydrorugulovasine A-lactam both in color reaction and in chromatographic behavior, besides chanoclavine-(I) and rugulovasine A and B, in a small quantity. Contrary to expectation, the existence of agroclavine and the other known tetracyclic ergoline alkaloids in the test cultures could not, after all, be found. Further, the state of increase and decrease of chanoclavines and rugulovasines (A and B) in the culturing process did not reveal any biogenetic relationship among these alkaloids. Of the newly found indole alkaloids mentioned above, the one which was considered to be chanoclavine-(II) has been isolated exclusively as rac. chanoclavin-(II).
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