糸状菌のα-ケトグルタール酸生成について

概要

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1. By using the method of paper-chromatography, the organic acids production by molds in ghicose medium were extensively studied. Among 14 strains of Asp. oryzae, three strains were found that they produced α-ketoglutaric acid along with other acids such as kojic, citric, malic, lactic, succinic and fumaric acids by surface culture. These acids except α-keto-lutarate were found by one of the authors(1) to be the products fo Asp. oryzae. 2. Two strains which did not produce α-ketoglutaric acid by surface culture formed this acid under a submerged state. 3. Two strains of Rhizopus belonging to fumaric acid former produced α-ketoglutaric acid by surface culture. The fact was confirmed not only by the method of paper-chromato-graphy, but also by obtaining the pure material from the fermentation medium as 2, 4-dini-trophenylhydrazone. 4. Recently WALKER et al.(2) reported the presence of α-ketoglutaric acid in the fermentation medium of glucose by Asp. niger. As we found this acid not only in the medium of Asp. oryzae but also by Rhizopus species, so it may be concluded that α-ketoglutaric acid is a normal product of various molds in glucose medium.
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