Presence of Infectious RD-114 Virus in a Proportion of Canine Parvovirus Isolates
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概要
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We recently found that certain canine live attenuated vaccines produced using non-feline cell lines were contaminated with an infectious feline endogenous retrovirus, termed RD-114 virus. We suspected that RD-114 virus may have contaminated the seed stock of canine parvovirus (CPV) during the production of the contaminated vaccines. In this study, we collected stock viruses of CPVs propagated in a feline cell line, and checked the presence of infectious RD-114 virus. Consequently, we found that RD-114 viral RNA was present in all stock viruses, and 7 out of 18 stock viruses were contaminated with infectious RD-114 virus. We also found that RD-114 virus was stable physically and is capable of retaining its infectivity for a long period at －80℃.
著者
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MIYAZAWA Takayuki
Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto U
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YOSHIKAWA Rokusuke
Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto U
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Sato Eiji
Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto U
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MIYAZAWA Takayuki
Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University
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SATO Eiji
Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University
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