Merkel cell carcinomaの1例

概要

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A case of an 86-year-old man with Merkel cell carcinoma is reported. A small papule on the right cheek gradually enlarged, resulting in a dome-shaped nodule in two months. Electron microscopically, the tumor cells contained 100 to 150nm dense-core granules and aggregation of intermediate filaments in the cytoplasm. Immunocytochemically, the cells were positive for neuron-specific enolase, cytokeratins (CAM5.2 and MA902) and epithelial membrane antigen. Because the tumor rapidly enlarged in the next one month, interferon-β (3×106U, once a day) was intradermally injected around the tumor for 5 days. The tumor was then excised 2 cm apart from the margin.Neither tumor recurrence nor metastasis has been observed in a follow-up period of 18 months after surgery. Intralesional injections of interferon independently or in combination with excision may be preferable treatment modalities of Merkel cell carcinoma.