A case of verrucose epidermal growth disorders showing growth of various tumors.

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A-61-year-old man, sheet metal worker, of epidermodysplasia verruciformis (EV) with malignant changes was reported. There was no similar disease on his family. Since 16 year old, he notised erythematous flecks with no symptom on his back, chest and hands. At 55 years old, he was operated for squamous cell carcinoma on left eye-lid. The physical examination showed two tumors on his face and neck, egg-sized pigmented fleck with erythema on his chest and numerous been-sized erythema and hypopigmented flecks on his chest and back.The histological features of the bean sized erythema showed large clear cells in the granular layer. The nucleus of these cells positively stained with anti-human papillomavirus antibody. The lesion was diagnosed as EV.Histopathologically the tumors of his face and trunk were diagnosed as followings: the tumor on his left eye-lid was squamous cell carcinoma, the tumor on his neck was basal cell carcinoma with actinic keratosis, the egg-sized pigmented fleck was Bowen disease.Treatment with 5-FU cream for EV was effective.
日本皮膚悪性腫瘍学会の論文