Effect of peri-operatively administrated OK-432 on immunopotency in primary liver cancer. Immunological and histological study in cases recieving intrahepatic arterial administration.:Immunological and histological study in cases recieving intrahepatic ar

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OK-432 purified from streptoccocal preparations was administrated via either hepatic artery or peripheral vein to the patients with primary liver cancer to prevent the decrease of immunopotency in the peri-operative periods.In "OK-432 administration" group, the immunological parameters such Su-PS skin reactions, number of lymphocytes, NK activity, and Leu 11 positive cells of peripheral blood showed more increased levels than those in "untreated" group.Histologically, the resected specimens showed varying degrees of lymphocyte infiltration throughout the cancerous tissue in five out of nine patients who recieved OK-432 via hepatic artery. In patients recieved OK-432 via the hepatic artery which was feeding cancer lesion, there were formation of lymphfollicles in the cnacerous tissues and destruction of the cancer nests by infiltrating lymphocytes. Together with the immunoloigcal and histological findings, the intraarterial administration of OK-432 seemed to be useful as a multidisciplinary treatment.
財団法人日本消化器病学会の論文