Effect on uptake of D-glucose, L-leucine and L-leucylglycine into intestinal brush border membrane vesicles isolated from rats fed either oligopeptide or amino acid elemental diet.

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The uptake of D-glucose, L-leucine and L-leucylglycine into intestinal brush border membrane vesicles isolated from rats was investigated. They were fed either oligopeptide (SP group) or amino acid (AA group) elemental diets for four weeks.The results are as follows. As for L-leucine uptake, there was no significant difference in Km value between SP group and AA group. But Jmax value of SP group is significantly 1.7 times as large as that of AA group. As for L-leucylglycine uptake, there was no difference in Km value between the two groups, but Jmax value of SP group is significantly about twice as large as that of AA group. There is however, no difference in Km value and Jmax value between the both groups. These results indicate that L-leucine and L-leucylglycine transport carriers in the brush border membrane significantly increased in SP group compared with that in AA group, and that these carriers might be induced by oligopeptides as intraintestinal substrate.
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