重症潰瘍性大腸炎に対する白血球除去療法の有効性について : 繊維を用いた白血球系細胞除去療法

概要

論文の詳細を見る
We have attempted an open clinical study to evaluate leukocytapheresis therapy for patients with severe ulcerative colitis, using a leukocyte removal filter. Twelve patients were enrolled in the present study, and 10 failed to reach remission in spite of receiving an intensive regimen of intravenous prednisolone (1.0-1.5mg/kg body weight/day). LCAP was carried out once a week by using leukocytapheresis filter, lasting for several weeks. Seven patients (58.3%) demonstrated an improvement of clinial symptoms, and three patients (25%) reached the remission state. Peripheral lymphocytic popuultion, shown HLA-DR^+ HLA-DR^+ + CD3^+, HLA-DR^+ + CD4^+, and HLA-DR^+ + CD8^+ demonstrated no alteration before or after LCAP. LCAP is a useful therapeutic tool for patients with severe ulcerative colitis. and it can be thought that the exclusion of neutrophils may be a crucial mechanism of efficacy in LCAP for ulcerative colitis.
日本アフェレシス学会の論文
2000-02-29