The influence of theophylline on polyamine metabolism and colonic carcinogenesis induced by 1.2-dimethylhydrazine in mice.

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The administration of theophylline (120mg/kg•day, 14wk) to the drinking water of female BALB/c mice after treatment with 1, 2-dimethylhydrazine (DMH) (30mg/kg•sc, 1/wk, 14wk) resulted in both an increase in number of colon carcinoma and increases in ornithine decarbosylase (ODC) activities and polyamine (PA) levels in colon tissue. This increase in number of colon carcinoma was about 3-fold to mice receiving same amount of DMH and drinking water without theophylline. ODC activities (pmoles 14CO2/hr/mg prot, mean±SD) in colon tissue were 122±10.6 (n=6) in DMH with theophylline group, 28.3±2.13 (n=8) in DMH alone group, 21.3±1.67 (n=6) in control group respectively. Putrescine and spermidine levels (nmoles/g, mean±SD) were 31.0±10.5, 527±86.6 (n=11) in DMH with theophylline group, 24.0±11.4, 464±129 (n=11) in control group respectively. Thus with marked increase of ODC activities and slight increase of PA levels, theophylline has shown to significantly enhance the promoting phase of carcinogenic process with DMH.
財団法人日本消化器病学会の論文