低分子ペプチド食投与のアミノ酸吸収に及ぼす影響とその機序について

概要

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The effect of feeding a small-peptide elemental diet on brush border membrane aminopeptidase activities and amino acid absorption in guinea-pigs was investigated. The latter effect and its mechanism were studied by measuring the transmural potential difference. Aminopeptidase activities on brush border membrane were significantly higher in the group fed a small-peptide elemental diet (SP group) than in the group fed an amino acids elemental diet (AA group).In the SP group, the absorption of both glycyl-L-leucine and L-leucine was greater than that in the AA group. The increase of ΔPDmax of L-leucine in the SP group indicated that the acceleration of mucosal uptake of an amino acid in the SP group was due to an increased number of carriers.
財団法人日本消化器病学会の論文