A study on the role of the microtubules on water and electrolyte transport in the rat intestine.

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Although the mechanism of water and electrolyte transport in the intestine has been clarifed, the role of the microtubules on water and electrolyte transport has remained obscure.We examined the effect of colchicine, an inhibitor of the microtubules, on water and electrolyte transport in the rat intestine, and we came to the following conclusion.Pathophysiology of the colchicine induced diarrhea consists of two factors. One is the decrease of water and electrolyte absorption due to inhibition of Na-K ATPase activity. The other is the increase of water and electrolyte secretion due to an increase of Ca ion and cyclic GMP. This increase of cyclic GMP results from the increase of Ca ion. This secretion is inhibited by the Ca channel blocker.Our experiments indicate that the microtubules plays an important role, the regulation of Ca ion concentration in the intestinal epitherial cell, on water and electrolyte transport in the intestine.
財団法人日本消化器病学会の論文