Effect of oligopeptides as intraluminal substrates upon brush border aminopeptidase and cytosol peptidase activities.

概要

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Aminopeptidase activities in brush border membrane fractions were significantly higher in the group on a small peptides elemental diet (SP-ED) than in the group on an amino acids elemental diet (AA-ED). In those on SP-ED, aminopeptidase activities showed an enzymic gradient along the villus crypt axis with time and became completely distributed in the villus. The elevation of activities was inhibited by cycloheximide and was a reversible response. In this way we made it clear that brush border aminopeptidase was one of the adaptation enzymes induced by oligopeptides as intraluminal substrates. Cytosol dipeptidase activities were also higher in the group on SP-ED than in those on AA-ED, and the former showed increases in the absorption of dipeptide (glycyl-L-leucine) and amino acids (glycine, L-leucine) in vitro experiment on the small intestine.
財団法人日本消化器病学会の論文