Stereological estimation of zymogen granules in panceratic acinar cells and its clinical significance.

概要

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In order to clarify the correlation between exocrine pancreatic function and morphological changes in minimal pancreatic damage, numbers and size of zymogen granules of pancreatic acinar cells were stereologically estimated at the ultrastructural level, and PFD tests were carried out.The results of PFD test revealed lower than normal ranges in 41% of the patients with biliary tract diseases and all patients with chronic pancreatitis. Mean diameter of zymogen granules varied widely in size from 0.4 to 1.5μm, were significantly smaller in the patients with chronic pancreatitis and biliary tract diseases with impaired exocrine pancreatic function as compared to the patients with biliary tract diseases with normal exocrine pancreatic function. Urinary PABA recovery rate was observed significantly correlated with mean diameter and quantities of zymogen granules in unit volume of acinar cell cytoplasm. These findings suggest that ultrastructural changes of zymogen granules are closely related to the exocrine pancreatic function, and may explain the pathogenesis of pancreatic dysfunction.
財団法人日本消化器病学会の論文