Assessment of microsomal functional mass by aminopyrine breath test in the rats with D-galactosamine injured liver followed by partial hepatectomy.

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Aminopyrine breath test (ABT) as en index of hepatic microsomal function was performed on the rats with D-galactosamine (D-Gal)-injured liver before andafter 68% partial hepatectomy. D-Gal 1600mg/kg induced the maximum decrease of ABT score on 2 days after the administration, which returned to normal very incidiously. Following partial hepatectomy ABT scores decreased to the level correlated closely with hepatectomized weight. Howerver in the D-Gal pretreated rats, ABT scores decreased more remarkably than those in normal rats after partial hepatectomy and the decreased ABT scores recovered later. ABT scores measured just before partial hepatectomy reflected a surgical mortality with a significant difference, survivors 53.4±23.0% vs deaths 18.4±12.6% (p<0.01). Hepatic microsomal function measured by ABT reflected the hepatic functional mass in D-Gal injured rats followed by partial hepatectomy and predicted the surgical mortality with a significant difference.
財団法人日本消化器病学会の論文