Effect of splenectomy on liver regeneration after partial hepatectomy. On the metabolism of polyamine.:On the Metabolism of Polyamine

概要

論文の詳細を見る
The effect of splenectomy on hepatic polyamine content and DNA synthesis was studied in rat liver regeneration after partial hepatectomy. The activity of ornithine decarboxylase (ODC), a rate-limiting enzyme in polyamine biosynthesis, markedly increased in the early stages of liver regeneration, and the increase in this enzyme activity was significantly enhanced in splenctomized rats. The effect of splenectomy was specific for the induction of ODC, since tyrosine aminotransferase activity was not affected. Splenectomy also enhanced increases in hepatic polyamines and DNA synthesis in the regenerating liver. These results suggest that splenectomy affects liver regeneration after partial hepatectomy by enhancing the induction of ODC activity, which is an important early biochemical event in liver regeneration.