持続的局所熱希釈法を用いたヒト門脈血流量測定に関する研究(第一報)

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Ganz's thermistor catheter was originally developed to determine human coronary sinus blood flow, which is low compared with that of the portal vein. To use this device determining portal blood flow, we prepared a model circuit with high flow, and examined its appropriateness and reproducibility.There was a significant regression between calculated (X) and measured (Y) blood flow rate while the thermal indicator was being injected at a constant rate of 48ml/min with blood flow rates of 240 to 1, 148ml/min in this circuit. The regression equation was Y=1.15X-22.6 (r=0.9949, p<0.001). Reproducibility was satisfactory.We used this catheter inserted in the portal trunk by percutaneous transhepatic portal catheterization to determine portal blood flow. The circuit was the same as before. Fifty-five such measurements in 26 cases showed portal blood flow ranging from 315 to 1, 513ml/min, with a mean of 713.5±277.8ml/min Reproducibility was excellent, with a random error of 3.9±2.9%. The portal blood flow in the 19 cases complicated with cirrhosis, 441.0±192.6ml/min/m2 was not significantly lower than in cases without cirrhosis, in which the mean was 509.2±187.5ml/min/m2.
財団法人日本消化器病学会の論文