Cell kinetics in the pancreatic ductal dysplasia. 3H-thymidine autoradiographical study during pancreatic carcinogenesis in syrian golden hamsters by N-nitosobis-(2-hydroxypropyl) amine.:3H-thymidine Autoradiographical Study During Pancreatic Carcinogenes

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3H-thymidine autoradiograpgical study was performed upon the pancreas during N-nitrosobis (2-hydrxypropyl) amine-induced carcinogenesis in Syrian golden hamsters. The results are shown as follows:It was generally observed that the percentage of the labeled unclei (labeling index) increased as the dysplastic grade increased. The dysplastic lesions with multilayered cells (grades III and IV) showed transient increases in labeling index between 7th to 10th day. Among the lesions with multilayered cells, labeling index was higher in monolayered cells (C group), which were directly contacting with basement membrane, than in other cells groups (A and B groups). Persistant decreases in labeling index were seen in C group after 3H-thymidine administration, whereas transient increases between 5th to 10th day was observed in A and B groups. In C group, the number of grains in labeled nuclei decreased more earlier and more remarkably than in A and B groups.From these results, it is suggestive that the unilayered cells contacting with basement membrane may play the proliferative center in the dysplastic lesion and have an invasive potency afterwards.
財団法人日本消化器病学会の論文