A HISTOCHEMICAL STUDY OF THE INTRACYTOPLASMIC MUCOSUBSTANCES ON CHRONIC PANCREATITIS AND PANCREATIC CARCINOMA

概要

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By using surgically resected specimens of the ductal carcinoma of the pancreas and chronic pancreatitis, differential components of the intracytoplasmic mucosubstances were studied histochemically.The following were obtained:1) The mucosubstances in the normal pancreatic epithelium were composed predominantly of neutral glycoproteins.2) In the epithelium of the chronic pancreatitis which accompanied marked fibrosis, the main components of the intracytoplasmic mucosubstances were both neutral and sialylated glycoproteins. These two kinds of mucosubstances were also generally found in various kinds of histological types of cancer cells.3) Sulfated glycoproteins and acid mucopolysaccharides such as chondroitin sulfate A and C were detected frequently in poorly differentiated tubular adenocarcinoma.4) These acid mucopolysaccharides were more frequently found in cancer cells in cancer stroma with a marked fibrosis (desmoplasia), suggesting that these polysaccharides play a role in promoting fibroplastic changes.
財団法人日本消化器病学会の論文