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Despite the fact that nonsteroidal antiinflammatory agents typically damage the mucosa of the upper gastrointestinal tract, little is known about its chronic effects. In order to determine whether chronic indomethacin ingestion (3mg/kg/day, for 4 weeks) affects epithelial proliferation, this study was performed by means of 3H-thymidine autoradiography. The results indicate that indomethacin stimulates epithelial proliferation in rat gastric fundus at doses which cause no detectable injury, indicating an adaptive response. The failure of indomethacin to stimulate epithelial proliferation in antrum or duodenum may account for in part for ulcerogenic action of the drug.
財団法人日本消化器病学会の論文