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Hemostatic function in 58 patients with gastric cancer were investigated. And, Activator (A) and Inhibitor (I) of fibrinolysis of 41 gastric cancer tissues were determined.The results were as follows: 1) The patients with Stage IV gastric cancer were in the state of chronic DIC. 2) In the non-recurrent group, the values of hemostatic function were almost normal and didn't change postoperatively. On the other hand, in the recurrent group, the values of PT, ATIII and α2PI decreased in almost all cases and an increase in α1AT were observed only in the patients with poor prognosis, postoperatively. 3) Furthermore, an increase in Fbg and decrease in Plg were observed in those who died of cancer. 4) There were I activity in the tissues of gastric cancer which were scarcely detected in the normal gastric mucosa. 5) There were correlation between A/I ratio and histological differentiative degrees of the cancer tissues. So A/I ratio seems to be useful to evaluate the biological potential of malignancy in the gastric cancer.
財団法人日本消化器病学会の論文