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The correlation between serum and liver tissue γ-glutamyl transpeptidase activities as determined by microassay method, was studied in needle biopsy samples taken from 41 patients with alcoholic liver disease, 104 patients with viral liver disease, 28 patients with drug-induced liver injury and 10 normal liver histology. Each of the mean activities of serum and liver tissue γ-GTP activities in patients with alocholic liver disease, and drug-induced liver injury was statistically higher than those of normal liver histology, respectively. The mean activities of serum and liver tissue γ-GTP in patients with alcoholic liver disease and cytotoxic drug-induced hepatitis were higher than those of viral liver disease, respectively. The mean activity of liver tissue γ-GTP in patients with cholestatic drug-induced liver injury was higher than that of cytotoxic liver injury. The frequencies of the grades of the γ-GTP activities of liver tissue taken from the patients with various liver diseases were statistically different in each of the grades of the changes of eosinophilic degeneration, necrosis and hydropic swelling of liver cells.