BACK DIFFUSION OF HYDROGEN IONS IN PEPTIC ULCERS:V. Hydrogen ion back diffusion in various gastric disorders and its participation in ulcer formation

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In order to investigate the possible relation of hydrogen ion back diffusion to theformation of gastric ulcers, the net flux of sodium ions into the luminal test solution (Na+net flux) and the back diffusion of luminal hydrogen ions (H+BD) were comparatively studied amoung 11 normal subjects and 153 patients with various gastric disorders. The results obtained were as follows. (1) Na+ net flux was significantly increased in patients with all kinds of gastric disorders in comparison with normal subjects. However, a significant increase in H+BD was found only in atrophic gastritis, gastric erosion and open gastric ulcer. (2) The patients with gastric ulcer were classified on the basis of the degree of accompanied atrophic gastritis, and compared with normal subjects and the patients with the same degree of atrophic gastritis without ulcer in terms of Na+ net flux and H+BD. No specific increase of H+BD was seen for the presence of gastric ulcer whereas in both groups with severe atrophic gastritis with and without gastric ulcer H+BD was significantly larger than in normal subjects. (3) When the patients with atrophic gastritis and gastric ulcer were classified by the presence or absence of accompanied gastric erosion, a significantly larger H+BD was observed in those patients with erosion than in normal subjects whereas in the patients without erosion no significant increase was seen. From the above findings, it has been concluded that the back diffusion of luminal hydrogen ions into the mucosa is closely related to the presence of gastric erosion which probably constitutes a part of the background of ulcer formation.

BACK DIFFUSION OF HYDROGEN IONS IN PEPTIC ULCERS:V. Hydrogen ion back diffusion in various gastric disorders and its participation in ulcer formation

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