HETEROTRANSPLANTATION OF THE HUMAN STOMACH CARCINOMAS INTO NUDE MICE:II. Growth Behavior of Various Histological Types and Prognosis of the Patient

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The growth behavior of various histological types of stomach carcinomas in nude mice and the prognosis of the patients were studied. Transplantability of 60 stomach cancer patients was 51% (31 out of 60 cases). The tumor growth pattern in the nude mice was classified as rapid type, slow type or persistent type. The growth pattern was not related to the histological types. However, there was a correlation between growth pattern and clinical stages of the patients. All of the tumors classified as stage 11 were the persistent type, and many of the tumors in stage III and stage IV were the rapid type. In Borrmann's classification, many of Borrmann 3 type tumors but none of the 4 type tumors showed the rapid type. The prognosis of the donor patients is as follows: In 8 cases whose tumors showed rapid type, 6 out of 8 died within 12 months after the operation and 2 out of them are still surviving 6 months after the operation; in 19 cases whose tumors showed persistent type, 7 out of 19 cases were survived more than 12 months and 9 out of them are still surviving.These results suggest that there might be a correlation between the growth pattern of the stomach carcinomas in nude mice and the prognosis of the patients.

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