LIVER CELL INJURY OF ANTINEOPLASTIC AGENTS AND INFLUENCE OF COENZYME Q10 ON THE CELLULAR K+ AND MEMBRANE PD IN THE RAT

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Simultaneous measurement of membrane potential (PD) and intracellular K+ concentration (CK) was performed on rat liver slices with double barreled potassium ion-selective microelectrodes, and the data were used for the judgement of cellular injury of antineoplastic agents. Further, an action of coenzyme Q10 minimizing the cellular injury was examined.Both the membrane PD and intracellular K+ concentration were significantly decreased by administration of antineoplastic agents (Mitomycin C "MMC" or 5-Fluorouracil Dry Syrup "5-FUDS").It is suggested, therefore, that both MMC and 5-FUDS would bring about a hypofunction of hepatic cells as a result of their side effects, being characterized by a decrease of cellular energy metabolilm, such as inabilities of cellular K+ accumulation and Na+ extrusion out of the cell. Administration of coenzyme Q10 was recognized to partially restore these abilities.Thus, it is considered that a certain side effects of antineoplastic agents on rat liver cells can be prevented, at least in part, by a combination therapy with the administration of coenzyme Q10.
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