Studies on the relationship between endocrine and exocrine pancreatic functions:Part I Exocrine pancreatic function in diabetes mellitus

概要

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Exocrine pancreatic function by means of pancreozymin secretin test was investigated in 21 control subjects and in 30 patients with diabetes mellitus.The results obtained were as follows:1. Significant decreases of volume, maximal bicarbonate concentration and amylase output of pancreatic juice were observed in diabetic patients compared with control subjects.2. These decreases were related to the condition of diabetic control, duration and complications of diabetes mellitus.3. Administration of insulin was closely related to the amelioration of amylase output, indicating that insulin would accelerate the synthesis or the secretion of the pancreatic amylase.4. A significant increase of immunoreactive glucagon, which was known to inhibit the amylase output from the pancreas, was observed in the plasma of diabetic patients.In conclusion, the most important factor of the pancreatic exocrine dysfunction in diabetes mellitus was attributed to a lack of insulin action and in addition a concomitant elevation of plasma glucagon, and an interaction of these hormones were to be considered.
財団法人日本消化器病学会の論文