CORRELATION BETWEEN CHANGES OF SUGAR METABOLISM AND BLOOD INSULIN AND GLUCAGON LEVELS IN LIVER DISEASES:Part II On the Responses of Blood IRI and IRG to Oral Glucose and Intravenous Arginine Administrations in Accordance with Glucose Tolerance

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概要

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• Pancreatic endocrine function, especially from the view point of changes in plasma insulin (IRI) and glucagon (IRG) levels, was investigated in patients with liver diseases during oral glucose (GT) and intravenous arginine administration in accordance with the glucose tolerance.The results obtained are as follows:1) Significantly higher responses to the increase in plasma IRI following glucose administration were commonly observed in groups of normal, borderline and/or diabetic conditions as compared with that of healthy control, showing lowest values in the diabetic group at the initial response after glucose loading as compared with those of the other groups.Plasma IRG levels sowed a significantly higher increases in all groups of liver diseases as compared with that of healthy control, and the highest values of IRG during oral glucose administration was found in the group with diabetic conditions.The molar ratio between insulin (I) and glucagon (G) in the diseased group of normal GT condition showed the same pattern as that in healthy control. However, different patterns of I/G molar ratio in both groups of borderline and/or diabetic GT conditions were observed as compared with that of healthy control.2) Significantly higher responses to the increase in IRI following arginine administration were commonly observed in all groups of liver diseases as compared with that of healthy control, showing the highest response in group of normal GT conditions and higher responses in the group of borderline GT condition as compared with that in group of diabetic GT condition.Plasma IRG levels were significantly higher in all groups of liver diseases as compared with that of healthy control. IRG levels were the highest in the group of diabetics and higher in the group of borderline GT conditions as compared with that in group of normal GT condition.The molar ratio showed different patterns in all groups of liver diseases as compared with that of healthy control, showing the lowest in group of diabetics and lower in group of borderline GT condition as compared with that in the group of normal GT condition.From the results thus obtained, it was conjectured that the glucose intolerance conditions which were found in patients with liver diseases might closely be related with the changes in increases in plasma IRI and IRG levels and with the abnormalmolar ratios of I/G.

• 財団法人 日本消化器病学会の論文

著者

• 鬼原 彰

  札幌医科大学保健医療学部

• 菊地 晃

  札幌医科大学内科学第1講座

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• CORRELATION OF THE CHANGES OF SUGAR METABOLISM AND THOSE OF BLOOD INSULIN AND GLUCAGON LEVELS IN LIVER DISEASES:Part 1. The Responses to Oral Glucose Administration
• Studies on the relationship between endocrine and exocrine pancreatic functions:Part I Exocrine pancreatic function in diabetes mellitus
• CORRELATION BETWEEN CHANGES OF SUGAR METABOLISM AND BLOOD INSULIN AND GLUCAGON LEVELS IN LIVER DISEASES:Part II On the Responses of Blood IRI and IRG to Oral Glucose and Intravenous Arginine Administrations in Accordance with Glucose Tolerance

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