CORRELATION OF THE CHANGES OF SUGAR METABOLISM AND THOSE OF BLOOD INSULIN AND GLUCAGON LEVELS IN LIVER DISEASES:Part 1. The Responses to Oral Glucose Administration
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Pancreatic endocrine function during oral glucose tolerance test was investigated in patients with liver disease and in normal control.The results obtained are as follows:1) Significantly higher increases of blood sugar following glucose administration were commonly observed in various liver diseases as compared with that of normal control, showing the highest values in liver cirrhosis and high values of blood sugar in chronic hepatitis as compared against that in acute hepatitis.2) plasma insulin levels also showed the same increase as blood sugar after glucose administration. Elevated plasma glucagon in a fasting state in various liver diseases decreased gradually following glucose loading, but significantly higher levels were maintained during oral glucose tolerance test as compared with that of normal control.3) The molar ratios between insulin (I) and glucagon (G) showed an increase in acute and chronic hepatitis after glucose loading. A decrease in values, however, was observed in liver cirrhosis at 30 minutes after glucose administration as compared with that in normal control.4) Responses of plasma insulin and glucagon to glucose administration in chronic active hepatitis were significantly higher than that in chronic inactive hepatitis. The I/G molar ratios were lower at 30 minutes in the former and higher from 60 to 120 minutes in the latter after glucose loading.5) Responses of plasma insulin to glucose administration in decompensated liver cirrhosis was significantly lower than that in compensated liver cirrhosis, but plasma glucagon was inversely higher in the former than that in the latter. The I/G molar ratios in decompensated liver cirrhosis were lower than that in compensated liver cirrhosis after glucose administration.From the results thus obtained in which the responses in plasma insulin and glucagon to oral glucose administration and changes of I/G molar ratios observed, corresponded to the disease status, compared with those in normal control, it was conjectured that the abnormalities in the pancreatic endocrine function might be closely related with glucose intolerance in patients with liver disease.
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- CORRELATION OF THE CHANGES OF SUGAR METABOLISM AND THOSE OF BLOOD INSULIN AND GLUCAGON LEVELS IN LIVER DISEASES:Part 1. The Responses to Oral Glucose Administration
- Studies on the relationship between endocrine and exocrine pancreatic functions:Part I Exocrine pancreatic function in diabetes mellitus
- CORRELATION BETWEEN CHANGES OF SUGAR METABOLISM AND BLOOD INSULIN AND GLUCAGON LEVELS IN LIVER DISEASES:Part II On the Responses of Blood IRI and IRG to Oral Glucose and Intravenous Arginine Administrations in Accordance with Glucose Tolerance