UROBILINOGEN EXCRETION IN THE URINE AND BACTERIAL OVERGROWTH IN THE JEJUNUM OF PATIENTS WITH JEJUNO-OR ILEO-TRANSVERSOSTOMY IN MAN

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The relationship between jejunal bacterial overgrowth and urobilinogen excretion in the urine was studied in 9 patients with jejuno-or ileotransversostomy and 3 healthy volunteers. Jejunal juice was obtained by intubation, and the total urobilinogen excretion in 24 hours was estimated by I2-H2O method by Watson.In 5 cases whose jejunal juice contained many bacterium such as E. coli and Streptococcus faecalis, 4 showed abnormally high urobilinogen excretion in the urine. In two of the cases with jejunal bacterial overgrowth, antibiotics (AB-PC, 1g daily) was administered, and the results was the marked decrease in urine urobilinogen excretion to the normal level, with negative bacterial growth in the jejunal juice. On the other hand, in 4 cases whose jejunal juice showed less growth (less than 105 colonies/ml) in culture, all excreted normal value of urobilinogen.It is suggested that the abnormally high urobilinogen excretion in the urine of such cases with anastomoses between small intestine and colon, is due to the overgrowth of bacterium in the jejunum.
財団法人日本消化器病学会の論文