CPK ELEVATION IN PANCREATITIS

概要

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Serum CPK level was examined in 5 cases of acute pancreatitis and 4 cases of relapsing pancreatitis who were admitted to Chukyo Hospital during the past one year. An elevation in serum CPK level was found in 4 cases of acute pancreatitis and in 2 cases of relapsing pancreatitis. The degree and duration of the CPK elevation seemed to be related to the seriousness of the disease. The greater part of CPK isozyme was occupied by MM component, and there were no abnormal patterns on ECG compatible with acute myocardial infarction. These findings suggest that the origin of CPK in pancreatitis is retroperitoneal muscles and/or diaphragm. Following possibilities were considered as the etiologic factors of CPK elevation in pancreatitis:1) Muscular digestion and necrosis by pancreatic juice.2) Muscular microemboli due to local or disseminated intravascular clotting.3) Hyperpermeability of fascia and muscular cell membrane due to peripancreatic inflammation.4) Compression to muscles by hematoma or exudate.