PLASMA LEVELS OF CATECHOLAMINE AND CYCLIC 3'5'-ADENOSINE MONOPHOSHATE (c-AMP) IN LIVER DISEASE

スポンサーリンク

概要

• 論文の詳細を見る

• Plasma levels of catecholamine(CA) and c-AMP were studied in patients with liver disease in an attempt to evaluate the role of autonomic nervous as well as vascular system in liver disease. The patients consisted of the following: 22 cases of liver cirrhosis, 15 cases of chronic hepatitis, and 20 cases of acute hepatitis. CA was carried out by automatic rapid liquid chromatography and c-AMP was determined using CPBA method. Normal plasma values of epinephrine(EP), norepinephrine (NE) and c-AMP were as follows; below 0.12ng/ml, 0.04-0.35ng/ml and 8.3-13.5p molelml, respectively. CA values revealed that no elevation of EP was found in all patients examined; whereas a rise in NE was solely seen in patients with liver cirrhosis, showing in 17 out of 22 (77.3%) elevated and the value was 0.55±0.37ng/ml (mean±S.D.) (p<0.01). On the other hand, c-AMP indicated comparatively high in the patients with acute hepatitis (20.3±8.3) and in those with liver cirrhosis (24.2±8.9), contrasting with the lowered levels in those with chronic hepatitis (13.9±3.3) (p<0.01). In comparing these data with other laboratory findings in the patients with liver cirrhosis, NE had a correlation with the serum levels levels of gammaglo-bulin (r=0.6514, t=3.84>2.90). Furthermore, hepatic angiography showed marked cork screw appearance in the cases with elevated NE values.The data obtained lend strong support to the view that derangement of sympathetic nervous system with resultant disorder of vasoactive substances are involved in chronic liver disease, and c-AMP may be responsible for the repair of wound tissue.

• 財団法人 日本消化器病学会の論文

著者

• 山田 伸夫

  北里大学内科

• 石井 公道

  北里大学内科

• 柴田 久雄

  北里大学内科

• 岡部 治弥

  北里大学内科

• 石井 公道

  北里大学内科消化器部門

• 中沢 秀昭

  北里大学内科消化器部門

• 中沢 秀昭

  北里大学内科

• 山田 伸夫

  北里大学内科消化器部門

関連論文

• 経皮経肝胃静脈塞栓術により,食道静脈瘤の治療を行った,先天性肝線維症の一例
• メソトレキセート長期投与例にみられた肝障害の1例
• 実験的肝硬変における肝内微小血管の変化 : とくに,偽小葉結節の形成・増大過程における肝動脈の意義についての検討
• タイトル無し
• ACASEOF PRIMARY B-CELL ORIGIN LYMPHOMA OF THE STOMACH SEEN DURING DIPHENYL- HYDANTOIN THERAPY
• タイトル無し
• :AND DIFEERENTIAL DIAGNOSIS OF CHOLELIASIS
• A CASE OF CHRONIC RELAPSING PANCREATITIS ACCOMPANIED WITH PANCREATICOPLEURO INTERNAL FISTULA WHICH CAUSED RIGHT PLEURAL EFFUSION
• PLASMA LEVELS OF CATECHOLAMINE AND CYCLIC 3'5'-ADENOSINE MONOPHOSHATE (c-AMP) IN LIVER DISEASE
• A CASE OF ADULT FORM HYPERCITRULLINEMIA WITH CONSCIOUSNESS DISTURBANCE AND MARKED HYPERTRANSAMINASENEMIA AFTER DERIVARY

スポンサーリンク