地域集団における無症状胆石の疫学的研究

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概要

• 論文の詳細を見る

• Epidemiological surveys of asymptomatic gallstones were conducted in the towns of N (Aichi Prefecture) in 1980-1981 and S (Gifu Prefecture) in 1981. Of the 2, 321 people and the 1, 308 people (aged 30-65) in N and S town respectively, 1, 861 (827 males and 1, 034 females) were examined in the former and 1, 074 (486 males and 588 females) in the latter. This is a response rate of 80.2% for N and 82.1% for S. Examinations included anthropometric measurements, urinalysis, electrocardiography, serum lipids concentration, funduscopy and ultrasonography. Ultrasonography validity tests, performed on 213 people with clinically confirmed gallstones, gave sensitivity and specificity rates of 97.9% and 98.8%, respectively.Fifty-one out of the 2, 936 respondents had gallstones; all but two cases of which were asymptomatic gallstones. The overall prevalence of asymptomatic gallstones, was 0.5% for males and 2.7% for females, and the latter had a higher rate in each town. Gallstone rates were higher in N than in S, particularly in the ages over 40's, but were much lower than those found in Japanese urban areas. In order to evaluate the epidemiological characters of asymptomatic gallstones, a case-control study was attempted. Cases with asymptomatic gallstones were compared to people randomly selected, but matched by age, sex and residence, from the 2, 831 control subjects without any episodes of gallstone. Two respondents who had previous episodes had currently showed no clinical symptoms, were included above. Self-administered questionnaires provided information on previous illness, family history, current health status, and personal habits such as smoking, drinking and diet. Biochemical and physiological data, e. g. serum lipid concentration and electrocardiographic findings were compared.Matched analysis demonstrated higher mean serum triglyceride concentrations and earlier menopause in those with gallstones.

• 日本衛生学会の論文

著者

• 佐々木 隆一郎

  名古屋大学医学部予防医学

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