ラット胎仔に及ぼす解熱鎮痛薬 (アスピリン, アセトアミノフェン) の生殖生理学的および細胞遺伝学的影響

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The cytogenetic effects of analgesics and antipyretics on Sprague-Dawley rats, aged 8-18 weeks were examined. Aspirin or acetaminophen was administered to female rats for 2 weeks prior to mating. The doses of aspirin were 0 (controls-5% arabic gum sol.), 125 and 250mg/kg.b.wt. and those of acetaminophen 0 (controls), 500 and 1, 000mg/kg.b.wt. Treatment was continued until day 11.5 after copulation-copulation was at the 0.5 day- at which time, the animals were sacrificed and the fetuses were recovered. The fetuses were then analyzed cytogenetically by using a direct method for chromosome preparations.Chromosome anomaly frequencies were 0.9% (1/115), 5.1% (5/98) and 4.7% (4/85) respectively in the aspirin 0, 125 and 250mg/kg.b.wt. groups, and 7.1% (7/98) in the acetaminophen 500mg/kg.b.wt. and 4.8% (5/104) in the 1, 000mg/kg.b.wt. groups. A significant difference (p=0.019) was found only for the control group and the 500mg/kg.b.wt. acetaminophen group.When the differences were analyzed as to anomaly type, triploid occurrence was not related to drug treatment. However, aneuploid formation increased significantly after treatment with either drug: controls; 0.0% (0/115), aspirin 125mg/kg.b.wt.; 5.1% (5/98), aspirin 250mg/kg.b.wt.; 4.7% (4/85), acetaminophen 500mg/kg.b.wt.; 6.1% (6/98) and acetaminophen 1, 000mg/kg.b.wt.; 4.8% (5/104). The karyotypes were all mosaics, consisting of monosomy/normal or trisomy/normal cells.The results, therefore, suggest that treatment with aspirin or acetaminophen during pregnancy induces mosaic aneuploidy in F1 fetuses.

ラット胎仔に及ぼす解熱鎮痛薬 (アスピリン, アセトアミノフェン) の生殖生理学的および細胞遺伝学的影響

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