Structure-Melanotropic Activity Relationship in Synthetic Polypeptides Related to ACTH
スポンサーリンク
概要
- 論文の詳細を見る
Melanotropic (MSH) activities of synthetic octadeca and tetracosa-peptides were compared with those of α-MSH, β-human-MSH, and porcine ACTH. The MSH activity was determined by in vivo approach using a newly devised reflectance meter to measure the skin colour of <I>Xenopus</I> frog. From the shapes of their time-response curves, α-MSH, Gly<SUP>1</SUP>-ACTH (1-18) amide (I), and β-Ala<SUP>1</SUP>-ACTH (1-18) amide (II) werefound to be of short action, whereas two long chain peptides, porcine ACTH and ACTH (1-24)-OH were of comparatively long action.β-human-MSH, Orn<SUP>15</SUP>-ACTH (1-18) amide (III), and βA-Ala<SUP>1</SUP>, D-Phe7, Orn<SUP>15</SUP>-ACTH (1-18) amide (IV) possessed extremely prolonged activity. The MSH potencies of these peptides were calculated from the dose required to give a minimal melanotropic response and were ranked as IV>β-human-MSH=II=III>ACTH=ACTH (1-24) OH>I.Compound IV was found to be about 400 times as potent as native ACTH. This ranking differs slightly from that found in the <I>in vitro</I> MSH assay proposed by Inouye <I>et al</I>.(1970 b) and is markedly different from the ranking in steroidogenic and lipolytic activities proposed by Tanaka (1971). The structure-activity relation and possible mechanism for these properties are discussed.
- 社団法人 日本内分泌学会の論文
著者
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TANAKA AKIRA
Shionogi Research Laboratory, Shionogi Co. Ltd.
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Hirata Masaharu
Shionogi Research Lab. Kanzakigawa Lab.
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Nakamura Masuhisa
Shionogi Research Laboratories Shionogi & Co. Ltd.
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INOUE SAKAE
Institute of Endocrinology, Gunma University
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Inoue Sakae
Institute Of Biology Tohoku University
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TANAKA AKIRA
Shionogi Research Laboratory
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HIRATA MASAHARU
Shionogi Research Laboratory
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